Biochemical engineers can now download a piece of software and, with a few simple clicks, assemble the DNA for new life forms through their laptops.
“With the proper computer tools, biologists can write their own genetic code -- and then turn that code into life,” said biochemist Omri Amirav-Drory, who founded Genome Compiler Corp., the company that built the software.He demonstrated for FoxNews.com at a Starbucks early one morning by manipulating a bacteria's genes on his MacBook.
The left side of the Genome Compiler app lists folders for known viruses, bacteria and other organisms, each storing files of genome sequences, the unique biological stamp encoded in an organism's DNA. The software offers tools to add extra genes, mutate proteins, or toss in a few amino acids.
If a particular genetic sequence is not in the list, the compiler downloads it from a library at the National Institute of Health. Once satisfied with the results, a scientist can save her invention to a file, click the order button and ship the virtual creature’s specs to a DNA synthesizing lab such as GenScript or GeneArt, which can assemble actual physical DNA based on the specs.“You … send them a text file and they would send you back a physical DNA,” Amirav-Drory told FoxNews.com.
The synthetic biology app is still in beta; on Jan. 15, the company added an undo feature and support for new DNA file formats. Building creatures is increasingly like word processing, it would seem. But such is the strange reality in the age of cheap genome sequencing, DNA synthesizing and "bioinformatics." A Fulbright Scholar with a Ph.D. from Tel Aviv University, Amirav-Drory has simply merged two fields: computer science and biochemical engineering.
“Computers understand code and living things understand the language of DNA,” he said. The software has built-in biosecurity measures to stop someone from building Ebola and other deadly agents, Amirav-Drory said, and assembling complex creatures that think is still far, far off. But it will let scientists program simple new microorganisms that can clean our air and water or produce energy just by coding their DNA in a certain way.ohn Cumbers, a synthetic biologist at the NASA Ames Research Center who has been using the genome compiler, says it speeds up his DNA work approximately ten times.